Полиморфизм гена моноаминооксидазы (МАОА) и вариативность психологических черт
DOI:
https://doi.org/10.54359/ps.v4i20.807Ключевые слова:
полиморфизм моноаминооксидазы, генотип-средовое взаимодействие, агрессивность, черты личностиАннотация
В молекулярно-генетических исследованиях показано, что генетические полиморфизмы (разные варианты одного и того же гена) определяют индивидуальные различия по целому ряду признаков, связанных с патологией, и одновременно – индивидуальные различия по психологическим признакам, варьирующим в пределах нормы. Обзор посвящен исследованиям вариативности психологических признаков, связанной с полиморфизмом гена МАОА, который кодирует фермент моноаминооксидазу, разрушающий моноамины и поддерживающий относительно постоянный уровень моноаминов в тканях. Анализируются исследования, в которых 1) генетическая вариативность рассматривается как одна из причин вариативности отдельных психологических признаков (асоциального поведения, тревожности, депрессивности, диспозиционных черт личности); 2) используется модель генотип-средового взаимодействия (оценивается влияние генетических предпосылок на психологические признаки в зависимости от ситуации развития); 3) рассматривается взаимодействие полиморфизмов гена МАОА с полиморфизмами ряда других генов и их совместное влияние на вариативность психологических признаков.
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