Полиморфизм гена моноаминооксидазы (МАОА) и вариативность психологических черт
DOI:
https://doi.org/10.54359/ps.v4i20.807Ключевые слова:
полиморфизм моноаминооксидазы, генотип-средовое взаимодействие, агрессивность, черты личностиАннотация
В молекулярно-генетических исследованиях показано, что генетические полиморфизмы (разные варианты одного и того же гена) определяют индивидуальные различия по целому ряду признаков, связанных с патологией, и одновременно – индивидуальные различия по психологическим признакам, варьирующим в пределах нормы. Обзор посвящен исследованиям вариативности психологических признаков, связанной с полиморфизмом гена МАОА, который кодирует фермент моноаминооксидазу, разрушающий моноамины и поддерживающий относительно постоянный уровень моноаминов в тканях. Анализируются исследования, в которых 1) генетическая вариативность рассматривается как одна из причин вариативности отдельных психологических признаков (асоциального поведения, тревожности, депрессивности, диспозиционных черт личности); 2) используется модель генотип-средового взаимодействия (оценивается влияние генетических предпосылок на психологические признаки в зависимости от ситуации развития); 3) рассматривается взаимодействие полиморфизмов гена МАОА с полиморфизмами ряда других генов и их совместное влияние на вариативность психологических признаков.
Скачивания
Библиографические ссылки
Alfimova M.V., Golimbet V.E., Egorova M.S. Lichnostnye cherty, upravlyayushchie funktsii i geneticheskie osobennosti metabolizma monoaminov // Psikhologiya. Zhurnal Vysshei shkoly ekonomiki. 2009. T. 6, N 4. S. 24–41. [in Russian]
Allen B. An analysis of the impact of diverse forms of childhood psychological maltreatment on emotional adjustment in early adulthood // Child Maltreatment. 2008. Vol. 13. P. 307–312. DOI: https://doi.org/10.1177/1077559508318394
Beach S.R.H., Brody G.H., Gunter T.D., Packer H., Wernett P., Philibert R.A. Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder // Journal of Family Psychology. 2010. Vol. 24. P. 12–20. DOI: https://doi.org/10.1037/a0018074
Brunner H.G., Nelen M., Breakefield X.O., Ropers H.H., van Oost B.A. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A // Science. 1993. Vol. 262. P. 578–580. DOI: https://doi.org/10.1126/science.8211186
Buckholtz J.W., Callicott J.H., Kolachana B., Hariri A.R., Goldberg T.E., Genderson M. Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality // Molecular Psychiatry. 2008. Vol. 13. P. 313–324. DOI: https://doi.org/10.1038/sj.mp.4002020
Buckholtz J.W., Meyer-Lindenberg A. MAOA and the neurogenetic architecture of human aggression // Trends in Neuroscience. 2008. Vol. 31. P. 120–129. DOI: https://doi.org/10.1016/j.tins.2007.12.006
Cadore R.J., Yates W.R., Troughton E., Woodworth G., Stewart M.A. Genetic-environmental interaction in the genesis of aggressivity and conduct disorders // Archives of General Psychiatry. 1995. Vol. 52. P. 916–924. DOI: https://doi.org/10.1001/archpsyc.1995.03950230030006
Cadoret R.J., Yates W.R., Troughton E. Adoption study demonstrating two genetic pathways in drug abuse // Archives of General Psychiatry. 1995. Vol. 2. P. 42-45. DOI: https://doi.org/10.1001/archpsyc.1995.03950130042005
Canli Т., Ferria J., Duman E.A. Review. Genetics of emotion regulation // Neuroscience. 2009. Vol. 164. P. 43–54. DOI: https://doi.org/10.1016/j.neuroscience.2009.06.049
Carter J.V., Schulsinger F., Parnas J. A multivariate predictive model of Schizophrenia // Schizophrenia Bulletin. 2002. Vol. 28. P. 649-682. DOI: https://doi.org/10.1093/oxfordjournals.schbul.a006971
Caspi A., McClay J., Moffitt T.E., Mill J., Martin J., Craig I.W., Taylor A., Poulton R. Role of genotype in the cycle of violence in maltreated children // Science. 2002. Vol. 297(5582). P. 851–854. DOI: https://doi.org/10.1126/science.1072290
Cicchetti D., Rogosch F.A., Sturge-Apple M.L. Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds // Development and Psychopathology. 2007. Vol. 19. P. 1161–1180. DOI: https://doi.org/10.1017/S0954579407000600
Comijs H.C., Beekman A.T.F., Smit F., Bremmer M., Van Tilburg T.G., Deeg D.J.H. Childhood adversity, recent life events and depression in late life // Journal of Affective Disorders. 2007. Vol. 103(1/3). P. 243-246. DOI: https://doi.org/10.1016/j.jad.2007.01.012
DeLisi M., Piquero A.R. New frontiers in criminal careers research, 2000–2011: A state-of-the-art review // Journal of Criminal Justice. 2011. Vol. 39. P. 289–301. DOI: https://doi.org/10.1016/j.jcrimjus.2011.05.001
Denney R.M., Koch H., Craig I.W. Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat // Human Genetics. 1999. Vol. 105. P. 542–551. DOI: https://doi.org/10.1007/s004390051143
Doornbos B., Janneke Dijck-Brouwer D.A., Kema I.P., Tanke M.A.C., Van Goor S.A., Muskiet F.A.J., Korf J. The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT // Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009. Vol. 33(7). P. 1250-1254. DOI: https://doi.org/10.1016/j.pnpbp.2009.07.013
Ducci F., Enoch M.A., Hodgkinson C., Xu K., Catena M., Robin R.W., Goldman D. Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women // Molecular Psychiatry. 2007. Vol. 13. P. 334–347. DOI: https://doi.org/10.1038/sj.mp.4002034
Egorova M.S., Parshikova O.V., Pyankova S.D. Variativnost' regulyatornykh kharakteristik i polimorfizm MAOA. 2012. (in Press) [in Russian]
Eley T.C., Sugden K., Corsico A. Gene-environment interaction analysis of serotonin system markers with adolescent depression // Molecular Psychiatry. 2004. Vol. 9. P. 908–915. DOI: https://doi.org/10.1038/sj.mp.4001546
Ferguson C.J., Beaver K.M. Natural born killers: The genetic origins of extreme violence // Aggression and Violent Behavior. 2009. Vol. 14. P. 286–294. DOI: https://doi.org/10.1016/j.avb.2009.03.005
Ferguson C.J. Genetic contributions to antisocial personality and behavior: A meta-analytic review from an evolutionary perspective // The Journal of Social Psychology. 2010. Vol. 150. P. 160−180. DOI: https://doi.org/10.1080/00224540903366503
Foley D.L., Eaves L.J., Wormley B., Silberg J.L., Maes H.H., Kuhn J., Riley B. Childhood adversity, monoamine oxidase A genotype, and risk for conduct Disorder // Archives of General Psychiatry. 2004. Vol. 61. P. 738–744. DOI: https://doi.org/10.1001/archpsyc.61.7.738
Guo G., Ou X.-M., Roettger M., Shih J.C. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: Associations and MAOA promoter activity // European Journal of Human Genetics. 2008. Vol. 16. P. 626–634. DOI: https://doi.org/10.1038/sj.ejhg.5201999
Hakamata Y., Takahashi N., Ishihara R., Saito S., Ozaki N., Honjo S., Ono Y., Inada T. No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females // Neuroscience Letters. 2005. Vol. 389. P. 121–123. DOI: https://doi.org/10.1016/j.neulet.2005.03.075
Horwitz A.V., Widom C.S., McLaughlin J., White H.R. The impact of early childhood abuse and neglect on adult mental health: A prospective study // Journal of Health and Social Behavior. 2001. Vol. 42. P. 184–201. DOI: https://doi.org/10.2307/3090177
Huang Y.Y., Cate S.P., Battistuzzi C., Oquendo M.A., Brent D., Mann J.J. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences // Neuropsychopharmacology. 2004. Vol. 29. P. 1498–1505. DOI: https://doi.org/10.1038/sj.npp.1300455
Huizinga D., Haberstick B.C., Smolen A., Menard S., Young S.E., Corley R.P., Stallings M.C., Grotpeter J., Hewitt J.K. Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype // Biological Psychiatry. 2006. Vol. 60(7). P. 677–683. DOI: https://doi.org/10.1016/j.biopsych.2005.12.022
Keltikangas-Jarvinen L., Salo J. Dopamine and serotonin systems modify environmental effects on human behavior: A review // Scandinavian Journal of Psychology. 2009. Vol. 50. P. 574–582. DOI: https://doi.org/10.1111/j.1467-9450.2009.00785.x
Kendler K.S., Bulik C.M., Silberg J., Hettema J.M., Myers J., Prescott C.A. Childhood sexual abuse and adult psychiatric and substance use disorders in women: An epidemiological and cotwin control analysis // Archives of General Psychiatry. 2000. Vol. 57. P. 953–959. DOI: https://doi.org/10.1001/archpsyc.57.10.953
Kim S.J., Kim Y.S., Kim S.Y., Lee H.S., Kim C.H. An association study of catechol- methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans // Neuroscience Letters. 2006. Vol. 401. P. 154–158. DOI: https://doi.org/10.1016/j.neulet.2006.03.006
Kim-Cohen J., Caspi A., Taylor A., Williams B., Newcombe R., Craig I.W., Moffit T.E. MAOA, maltreatment, and gene-environment interaction predicting children’s mental health: New evidence and a meta-analysis // Molecular Psychiatry. 2006. Vol. 11. P. 903–913. DOI: https://doi.org/10.1038/sj.mp.4001851
McGowan P.O., Sasaki A., D'Alessio A.C., Dymov S., Labonté B., Szyf M., Turecki G., Meaney M.J. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse // Neuroscience. 2009. Vol. 12(3). P. 342–348. DOI: https://doi.org/10.1038/nn.2270
Moffitt T.E. The new look of behavioral genetics in developmental psychopathology: Gene-environment interplay in antisocial behaviors // Psychological Bulletin. 2005. Vol. 131(4). P. 533–554. DOI: https://doi.org/10.1037/0033-2909.131.4.533
Nikulina V., Widom C.S., Brzustowicz L.M. Child abuse and neglect, MAOA, and mental health outcomes: A prospective examination // Biological Psychiatry. 2011. DOI: https://doi.org/10.1016/j.comppsych.2011.04.037
Nilsson K., Sjöberg R.L., Damberg M., Leppert J., Öhrvik J., Alm P.O., Lindström L., Oreland L. Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity // Biological Psychiatry. 2006. Vol. 59(2). P. 121–127. DOI: https://doi.org/10.1016/j.biopsych.2005.06.024
Olsson C.A., Foley D.L., Parkinson-Bates M., Byrnes G., McKenzie M., Patton G.C., Morley R., Anney R.J.L., Craig J.M., Saffery R. Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression // Biological Psychology. 2010. Vol. 83(2). P. 159–165. DOI: https://doi.org/10.1016/j.biopsycho.2009.12.003
Reif A., Rosler M., Freitag C.M., Schneider M., Eujen A., Kissling C., Wenzler D., Jacob C.P., Retz-Junginger P., Thome J., Lesch K.P., Retz W. Nature and nurture predispose to violent behavior: Serotonergic genes and adverse childhood environment // Neuropsychopharmacology. 2007. Vol. 32. P. 2375–2383. DOI: https://doi.org/10.1038/sj.npp.1301359
Rhee S.H., Waldman I.D. Genetic and environmental influences on antisocial behavior: A meta-analysis of twin and adoption studies // Psychological Bulletin. 2002. Vol. 128. P. 490–529. DOI: https://doi.org/10.1037/0033-2909.128.3.490
Rutter M. Genes and Behavior. nature-nuture interplay explained. Oxford: Blackwell, 2006.
Sabol S.Z., Hu S., Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter // Human Genetics. 1998. Vol. 103. P. 273–279. DOI: https://doi.org/10.1007/s004390050816
Samochowiec J., Syrek S., Michal P., Ryzewska-Wodecka A., Samochowiec A., Horodnicki J., Zakrzewska M., Kucharska-Mazur J. Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers // Neuropsychobiology. 2004. Vol. 50. P. 174–181. DOI: https://doi.org/10.1159/000079111
Sartor C.E., Agrawal A., McCutcheon V.V., Duncan A.E., Lynskey M.T. Disentangling the complex association between childhood sexual abuse and alcohol-related problems: A review of methodological issues and approaches // Journal of Studies on Alcohol and Drugs. 2008. Vol. 69. P. 718–727. DOI: https://doi.org/10.15288/jsad.2008.69.718
Shiraishi H., Suzuki A., Fukasawa T., Aoshima T., Ujiie Y., Ishii G., Otani K. Monoamine oxidase A gene promoter polymorphism affects novelty seeking and reward dependence in healthy study participants // Psychiatric Genetics. 2006. Vol. 16. P. 55–58. DOI: https://doi.org/10.1097/01.ypg.0000199447.62044.ef
Sjoberg R.L., Nilsson K.W., Wargelius H.L., Leppert J., Lindstrom L., Oreland L. Adolescent girls and criminal activity: Role of MAOA-LPR genotype and psychosocial factors // American journal of medical genetics. Part B: Neuropsychiatric genetics. 2007. Vol. 144B(2). P. 159–164. DOI: https://doi.org/10.1002/ajmg.b.30360
Taylor A., Kim-Cohen J. Meta-analysis of gene-environment interactions in developmental psychopathology // Development and Psychopathology. 2007. Vol. 19. P. 1029–1037. DOI: https://doi.org/10.1017/S095457940700051X
Tochigi M., Otowa T., Hibino H., Kato C., Otani T., Umekage T., Utsumi T., Kato N., Sasaki T. Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase Genes // Neuroscience Research. 2006. Vol. 54. P. 180–185. DOI: https://doi.org/10.1016/j.neures.2005.11.003
Tsuchimine S., Yasui-Furukori N., Kaneda A., Saito M., Nakagami T., Sato K., Kaneko S. Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals // Progress in neuro-psychopharmacology and biological psychiatry. 2008. Vol. 32. P. 1932–1935. DOI: https://doi.org/10.1016/j.pnpbp.2008.09.012
Van Gestel S., Van Broeckhoven C. Genetics of personality: are we making progress? // Molecular Psychiatry. 2003. Vol. 8. P. 840–852. DOI: https://doi.org/10.1038/sj.mp.4001367
Vaughn M.G., DeLisi M., Beaver K.M., Wright J.P. DAT1 and 5HTT are associated with pathological criminal behavior in a nationally representative sample of youth // Criminal Justice and Behavior. 2009a. Vol. 36. P. 1103–1114. DOI: https://doi.org/10.1177/0093854809342839
Vaughn M.G., DeLisi M., Beaver K.M., Wright J.P. Identifying latent classes of behavioral risk based on early childhood manifestations of self-control // Youth Violence and Juvenile Justice. 2009b. Vol. 7. P. 16–31. DOI: https://doi.org/10.1177/1541204008324911
Weder N., Yang B.Z., Douglas-Palumberi H., Massey J., Krystal J.H., Gelernter J., Kaufman J. MAOA genotype, maltreatment, and aggressive behavior: The changing impact of genotype at varying levels of trauma // Biological Psychiatry. 2009. Vol. 65(5). P. 417–424. DOI: https://doi.org/10.1016/j.biopsych.2008.09.013
Widom K.S., Brzustowicz L.M. MAOA and the “cycle of violence:” Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior // Biological Psychiatry. 2006. Vol. 60(7). P. 684–689. DOI: https://doi.org/10.1016/j.biopsych.2006.03.039
Williams L.M., Gatt J.M., Kuan S.A., Dobson-Stone C., Palmer D.M., Paul R.H., Song L., Costa P.T., Schofield P.R., Gordon E. A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index // Neuropsychopharmacology. 2009. Vol. 34. P. 1797–1809. DOI: https://doi.org/10.1038/npp.2009.1
Yang M., Kavi V., Wang W., Wu Z., Hao W. The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects // Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011. DOI: https://doi.org/10.1016/j.pnpbp.2011.11.009
Young S.E., Smolen A., Hewitt J.K., Haberstick B.C., Stallings M.C., Corley R.P., Crowley T.J. Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: Failure to confirm in adolescent patients // American Journal of Psychiatry. 2006. Vol. 163. P. 1019–1025. DOI: https://doi.org/10.1176/ajp.2006.163.6.1019
Yu Y.W., Yang C.W., Wu H.C., Tsai S.J., Hong C.J., Chen M.C., Chen T.J. Association study of a functional MAOA-uVNTR gene polymorphism and personality traits in Chinese young females // Neuropsychobiology. 2005. Vol. 52. P. 118–121. DOI: https://doi.org/10.1159/000087556